Thursday, April 25, 2013
Publication and contact
Optical imaging of
structural and molecular features in intact brain tissue
A method of rendering
intact brain tissue amenable to optical imaging could help identify new drug
targets. Treatment of whole brains or brain tissue from mice, zebrafish and
humans with hydrogel monomers and an electrophoretic tissue-clearing
technique resulted in an optically transparent hydrogel-tissue hybrid. In
transformed tissue, multiple rounds of fluorescence imaging enabled
visualization of various features including long-range projections, protein
complexes and neurotransmitters. In a frontal lobe sample from a deceased
patient with autism, the method revealed interneuronal dendritic bridges that
were not seen in normal, age-matched tissue. Next steps could include using
the method to identify disease-related structural or molecular features in brain
tissue from models for CNS diseases.
Published online April 25, 2013
Patent and licensing status
Chung, K. et al. Nature;
published online April 10, 2013;
Contact: Karl Deisseroth, Stanford University, Stanford,
All contents Copyright © 1993-2016 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]