Thursday, April 25, 2013
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Transplantable kidney graft
from a decellularized kidney extracellular matrix (ECM)
A transplantable kidney
built on a decellularized kidney ECM could help guide the development of
functional grafts for patients undergoing kidney transplant. A detergent
solution was used to generate a decellularized rat kidney ECM matrix, which
was repopulated with a mix of rat neonatal kidney cells and human umbilical
vein endothelial cells. In rats, the bioengineered kidney grafted at an
orthotopic position had functionality, produced urine and did not show
bleeding or clot formation. Next steps include refining the culturing
protocol used to generate the engineered kidney.
Miromatrix Inc. is
developing engineered tissues and organs for transplant using the
decellularization and recellularization technology (see Regenerating the
kidney, page 10).
Published online April 25, 2013
Patent applications filed
by the University
of Minnesota and Massachusetts
General Hospital covering the technology; University of
Minnesota patent application licensed to Miromatrix; MGH patent application
available for licensing
Song, J.J. et al. Nat.
Med.; published online April 14, 2013;
Contact: Harald C. Ott, Massachusetts General Hospital,
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