Thursday, April 25, 2013
Publication and contact
Antitumor mechanism of gold
nanoparticles in ovarian cancer
Mouse and cell culture
studies suggest gold nanoparticles could be useful for treating ovarian
cancers by blocking the MAPK pathway and
epithelial-to-mesenchymal transition (EMT). In three human ovarian cancer
cell lines, unmodified, 20 nm gold nanoparticles had more potent
antiproliferative activity than unmodified gold nanoparticles that had
smaller or larger diameters. In the ovarian cancer cell lines, the 20 nm
nanoparticles inhibited MAPK activation and the secretion of proteins
associated with EMT. In two orthotopic mouse models for ovarian cancer, the
nanoparticles decreased tumor mass compared with saline. Next steps include
determining the mechanism by which the nanoparticles target cancer-associated
pathways and developing methods to further enhance their efficacy.
Published online April 25, 2013
status not applicable
Arvizo, R.R. et al.
Proc. Natl. Acad. Sci. USA; published online April 8,
Contact: Priyabrata Mukherjee, Mayo Medical School,
All contents Copyright © 1993-2017 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]