Thursday, April 25, 2013
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Antitumor mechanism of gold
nanoparticles in ovarian cancer
Mouse and cell culture
studies suggest gold nanoparticles could be useful for treating ovarian
cancers by blocking the MAPK pathway and
epithelial-to-mesenchymal transition (EMT). In three human ovarian cancer
cell lines, unmodified, 20 nm gold nanoparticles had more potent
antiproliferative activity than unmodified gold nanoparticles that had
smaller or larger diameters. In the ovarian cancer cell lines, the 20 nm
nanoparticles inhibited MAPK activation and the secretion of proteins
associated with EMT. In two orthotopic mouse models for ovarian cancer, the
nanoparticles decreased tumor mass compared with saline. Next steps include
determining the mechanism by which the nanoparticles target cancer-associated
pathways and developing methods to further enhance their efficacy.
Published online April 25, 2013
status not applicable
Arvizo, R.R. et al.
Proc. Natl. Acad. Sci. USA; published online April 8,
Contact: Priyabrata Mukherjee, Mayo Medical School,
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