Thursday, April 25, 2013
Publication and contact
Mouse models for
neurological disease controlled with cellular-scale optogenetic brain
Mice with cellular-scale
optogenetic devices implanted in the brain could be useful for developing new
models of neurological diseases. The cellular-scale device consisted of
wireless, microscale, inorganic light-emitting diodes and control circuits.
The device was implanted into mouse brain tissue via microneedle injection
and connected to lightweight, head-mounted power and wireless systems that
did not inhibit the animal's normal activities. In mice implanted with the
device and expressing channelrhodopsin-2
in midbrain dopaminergic neurons, wireless tonic stimulation of those neurons
decreased anxiety-like behaviors with an effect similar to that of nicotine.
Ongoing work includes using the devices to test neural stress circuits
related to depression, anxiety and addiction.
SciBX 6(16); doi:10.1038/scibx.2013.397
Published online April 25, 2013
Patent status undisclosed;
available for licensing or partnering
Kim, T.-i. et al.
Science; published online April 12, 2013;
Contact: Michael R. Bruchas, Washington University in St.
Louis School of Medicine, St. Louis, Mo.
Contact: John A. Rogers, University of Illinois at
Urbana-Champaign, Urbana, Ill.
All contents Copyright © 1993-2015 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]