Thursday, April 25, 2013
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Mouse models for
neurological disease controlled with cellular-scale optogenetic brain
Mice with cellular-scale
optogenetic devices implanted in the brain could be useful for developing new
models of neurological diseases. The cellular-scale device consisted of
wireless, microscale, inorganic light-emitting diodes and control circuits.
The device was implanted into mouse brain tissue via microneedle injection
and connected to lightweight, head-mounted power and wireless systems that
did not inhibit the animal's normal activities. In mice implanted with the
device and expressing channelrhodopsin-2
in midbrain dopaminergic neurons, wireless tonic stimulation of those neurons
decreased anxiety-like behaviors with an effect similar to that of nicotine.
Ongoing work includes using the devices to test neural stress circuits
related to depression, anxiety and addiction.
SciBX 6(16); doi:10.1038/scibx.2013.397
Published online April 25, 2013
Patent status undisclosed;
available for licensing or partnering
Kim, T.-i. et al.
Science; published online April 12, 2013;
Contact: Michael R. Bruchas, Washington University in St.
Louis School of Medicine, St. Louis, Mo.
Contact: John A. Rogers, University of Illinois at
Urbana-Champaign, Urbana, Ill.
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