Thursday, April 18, 2013
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chromatography (HPLC)-single-crystal diffraction (SCD) analysis to guide drug
HPLC-SCD analysis could be
used to determine structures of noncrystalline compounds or proteins to guide
drug development. Networked porous metal complexes, dubbed crystalline
sponges, adsorbed and provided regular order to noncrystalline compounds
collected from HPLC fractions. X-ray crystallography was then used to provide
the molecular structure of the guest molecules. As proof of concept, the
HPLC-SCD analysis revealed the structure of three polymethoxyflavones
extracted from orange peel and the structure and absolute configuration of miyakosyne
isolated from a marine sponge. Next steps include designing various
crystalline sponges to accommodate proteins and peptides and using the current
sponges for medicinal compound characterization and metabolic analysis. (see
sponges to aid X-ray analysis, page 6)
Published online April 18, 2013
Patent applications filed;
technique licensed by X-ray equipment company Rigaku
Inokuma, Y. et al.
Nature; published online March 27, 2013;
Contact: Makoto Fujita, The University of Tokyo, Tokyo,
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