Thursday, April 18, 2013
Publication and contact
In vitro 3D biomimetic model for angiogenic sprouting
vitro biomimetic model for angiogenic sprouting could be useful for
identifying and evaluating compounds for their ability to modulate
angiogenesis. The in vitro model consists of a pair of parallel
cylindrical channels in a 3D collagen matrix, in which one channel is lined
with endothelium and perfused with plain medium and the other channel is
unlined and perfused with medium enriched in angiogenic factors. The model
recapitulated several hallmarks of in vivo angiogenesis, including
sprouting, formation of filopodia-like protrusions and development of lumens.
In the model, a VEGFR-2 (KDR/Flk-1) inhibitor showed
that the vessels can switch between VEGF-dependent and
VEGF-independent angiogenesis. Researchers did not disclose next steps, which
could include using the model to screen for new antiangiogenic compounds.
Published online April 18, 2013
Patent application filed;
licensed to an undisclosed company
Nguyen, D.-H.T. et al.
Proc. Natl. Acad. Sci. USA; published online April 8, 2013;
Contact: Christopher S. Chen, University of Pennsylvania, Philadelphia,
All contents Copyright © 1993-2017 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]