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Disease models

In vitro 3D biomimetic model for angiogenic sprouting

An in vitro biomimetic model for angiogenic sprouting could be useful for identifying and evaluating compounds for their ability to modulate angiogenesis. The in vitro model consists of a pair of parallel cylindrical channels in a 3D collagen matrix, in which one channel is lined with endothelium and perfused with plain medium and the other channel is unlined and perfused with medium enriched in angiogenic factors. The model recapitulated several hallmarks of in vivo angiogenesis, including sprouting, formation of filopodia-like protrusions and development of lumens. In the model, a VEGFR-2 (KDR/Flk-1) inhibitor showed that the vessels can switch between VEGF-dependent and VEGF-independent angiogenesis. Researchers did not disclose next steps, which could include using the model to screen for new antiangiogenic compounds.

SciBX 6(15); doi:10.1038/scibx.2013.374
Published online April 18, 2013

Patent application filed; licensed to an undisclosed company

Nguyen, D.-H.T. et al. Proc. Natl. Acad. Sci. USA; published online April 8, 2013;
Contact: Christopher S. Chen, University of Pennsylvania, Philadelphia, Pa.