Thursday, April 18, 2013
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In vitro 3D biomimetic model for angiogenic sprouting
vitro biomimetic model for angiogenic sprouting could be useful for
identifying and evaluating compounds for their ability to modulate
angiogenesis. The in vitro model consists of a pair of parallel
cylindrical channels in a 3D collagen matrix, in which one channel is lined
with endothelium and perfused with plain medium and the other channel is
unlined and perfused with medium enriched in angiogenic factors. The model
recapitulated several hallmarks of in vivo angiogenesis, including
sprouting, formation of filopodia-like protrusions and development of lumens.
In the model, a VEGFR-2 (KDR/Flk-1) inhibitor showed
that the vessels can switch between VEGF-dependent and
VEGF-independent angiogenesis. Researchers did not disclose next steps, which
could include using the model to screen for new antiangiogenic compounds.
Published online April 18, 2013
Patent application filed;
licensed to an undisclosed company
Nguyen, D.-H.T. et al.
Proc. Natl. Acad. Sci. USA; published online April 8, 2013;
Contact: Christopher S. Chen, University of Pennsylvania, Philadelphia,
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