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Bacteriophage T4 co-delivery of DNA and proteins for prime-boost vaccines

Cell culture and mouse studies suggest co-delivery of DNA and proteins with bacteriophage T4 could be useful as a vaccine. In mice, intramuscular injection with bacteriophage T4 heads engineered to package the Yersinia pestis F1-V gene and display the Y. pestis F1-V protein and dendritic cell-specific mAbs against lymphocyte antigen 75
(LY75; DEC205) led to antibody and interferon-g (IFNG; IFNg) production, whereas injecting the analogous construct lacking the F1-V gene led to antibody production alone. Next steps include using the bacteriophage T4 heads to engineer vaccines for other infectious diseases.

SciBX 6(14); doi:10.1038/scibx.2013.351
Published online April 11, 2013

Patent application filed; unlicensed

Tao, P. et al. Proc. Natl. Acad. Sci. USA; published online March 25, 2013;
Contact: Venigalla B. Rao, The Catholic University of America, Washington, D.C.