Thursday, April 11, 2013
This week in techniques
T4 co-delivery of DNA and proteins for prime-boost vaccines
culture and mouse studies suggest co-delivery of DNA and proteins with
bacteriophage T4 could be useful as a vaccine. In mice, intramuscular
injection with bacteriophage T4 heads engineered to package the Yersinia
pestis F1-V gene and display the Y.
pestis F1-V protein and dendritic cell-specific
mAbs against lymphocyte
led to antibody and interferon-g (IFNG;
IFNg) production, whereas injecting the analogous construct
lacking the F1-V gene led to antibody production alone. Next steps
include using the bacteriophage T4 heads to engineer vaccines for other
Published online April 11, 2013
application filed; unlicensed
P. et al. Proc. Natl. Acad. Sci. USA; published online March 25, 2013;
Contact: Venigalla B. Rao, The
Catholic University of America, Washington, D.C.
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