This week in techniques



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Disease models

Transgenic rat model for Alzheimer's disease (AD)

A transgenic rat model for AD could help identify new therapeutic candidates to treat AD. The rats were engineered to express AD-associated mutant human amyloid precursor protein (APP) and presenilin 1 (PSEN1; PS1). The rats showed progressive accumulation and deposition of b-amyloid (Ab) and microtubule-associated protein-t (MAPT; TAU; FTDP-17) pathology in the brain and had progressive loss of neurons. Next steps include making the rat model available to the research community.

SciBX 6(14); doi:10.1038/scibx.2013.349
Published online April 11, 2013

Model unpatented; available for licensing

Cohen, R.M. et al. J. Neurosci.; published online April 10, 2013;
Contact: Terrence Town, Cedars-Sinai Medical Center, Los Angeles, Calif.
Contact: Robert M. Cohen, Emory University, Atlanta, Ga.