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Disease models

Induced neuroblastoma stem cells

An induced stem cell-like neuroblastoma cell line could be useful for studying the cancer. In culture, treatment of a standard neuroblastoma cell line with inhibitors of DNA methylation and histone deacetylation led to long-term expression of stem cell-associated markers. Mice grafted with these stem cell-like neuroblastoma cells showed higher rates of tumor formation and metastasis than mice receiving a standard neuroblastoma cell line. Next steps could include testing therapeutic candidates against the induced neuroblastoma stem cells.

SciBX 6(14); doi:10.1038/scibx.2013.347
Published online April 11, 2013

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Ikegaki, N. et al. Proc. Natl. Acad. Sci. USA; published online March 11, 2013;
Contact: Xao X. Tang, University of Illinois at Chicago, Chicago, Ill.