Thursday, March 21, 2013
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Formulation of T cell
vaccines for cancer
Mouse studies suggest
saline formulations of T cell-targeted cancer vaccines could provide greater
antitumor activity than conventional adjuvant carriers. In a mouse model for
melanoma, subcutaneous injection with a tumor antigen vaccine formulated in
incomplete Freund's adjuvant (IFA), a widely used oil-based carrier, caused
accumulation of antigen-specific T cells at the injection site and elicited
lower antitumor activity than injection of a saline-based control formulation
of the same antigen. Mice receiving the saline-based formulation with an
adjuvant cocktail of IL-2,
receptor 7 (TLR7)
agonist and an antibody against CD40
had higher levels of tumor-infiltrating T cells than mice receiving an
IFA-based vaccine. Next steps include optimizing the vaccine formulation to
maximize dendritic cell uptake of the antigen and testing the formulation in
an investigator-led trial for melanoma.
Published online March 21, 2013
status not applicable
Hailemichael, Y. et al.
Nat. Med.; published online March 3, 2013;
Contact: Willem W. Overwijk, The University of Texas MD
Anderson Cancer Center, Houston, Texas
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