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Chemiluminescence resonance energy transfer (CRET) for detection of myeloperoxidase (MPO)

An imaging method called CRET could help assess oxidative stress and inflammation in vivo. In resected lungs from mice challenged with proinflammatory lipopolysaccharide (LPS), CRET imaging yielded about 40-fold greater luminescence emission in response to MPO than a control non-CRET imaging method. In a mouse xenograft model for systemic breast cancer metastasis, CRET imaging detected all metastatic lesions via the associated MPO activity. Next steps include developing a clinical imaging system and clinical-grade imaging reagents.

SciBX 6(10); doi:10.1038/scibx.2013.252
Published online March 14, 2013

Patent application filed; available for licensing from PerkinElmer Inc.
Contact: Mark Roskey, PerkinElmer Inc., Waltham, Mass.

Zhang, N. et al. Nat. Med.; published online March 3, 2013;
Contact: Ning Zhang, Pharmaron, Beijing, China