Thursday, March 14, 2013
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matrix (ECM) hydrogel for treating heart failure following myocardial
porcine-derived ECM hydrogel could be useful for treating MI. In a porcine
model for MI, catheter-mediated delivery of the ECM hydrogel decreased
pathological left ventricular remodeling and increased cardiac function
compared with delivery of saline. In rats, the hydrogel was biodegradable and
biocompatible. In human blood samples, the hydrogel was hemo-compatible and
triggered minimal platelet activation. Next steps include scaled-up GMP
manufacturing of the clinical-grade version of the hydrogel, called VentriGel.
Inc.'s VentriGel is in preclinical development to prevent
left ventricular remodeling and reduce heart failure following MI (see
goes into pigs, page 10).
Published online March 14, 2013
Patents pending; licensed
to Ventrix; available for partnering from Ventrix
Seif-Naraghi, S.B. et
al. Sci. Transl. Med.; published online
Feb. 20, 2013;
Contact: Karen L. Christman, University of California, San
Diego, La Jolla, Calif.
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