Thursday, March 14, 2013
Publication and contact
matrix (ECM) hydrogel for treating heart failure following myocardial
porcine-derived ECM hydrogel could be useful for treating MI. In a porcine
model for MI, catheter-mediated delivery of the ECM hydrogel decreased
pathological left ventricular remodeling and increased cardiac function
compared with delivery of saline. In rats, the hydrogel was biodegradable and
biocompatible. In human blood samples, the hydrogel was hemo-compatible and
triggered minimal platelet activation. Next steps include scaled-up GMP
manufacturing of the clinical-grade version of the hydrogel, called VentriGel.
Inc.'s VentriGel is in preclinical development to prevent
left ventricular remodeling and reduce heart failure following MI (see
goes into pigs, page 10).
Published online March 14, 2013
Patents pending; licensed
to Ventrix; available for partnering from Ventrix
Seif-Naraghi, S.B. et
al. Sci. Transl. Med.; published online
Feb. 20, 2013;
Contact: Karen L. Christman, University of California, San
Diego, La Jolla, Calif.
All contents Copyright © 1993-2017 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]