Thursday, March 14, 2013
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Mucosal delivery to improve
cancer vaccine efficacy
Mouse studies suggest
cancer vaccines formulated for mucosal delivery could have better efficacy
against mucosal tumors than vaccines delivered via subcutaneous injection. In
orthotopic mouse models for mucosal tissue head and neck cancers, an
intranasal formulation of a Shiga toxin-based cancer vaccine decreased tumor
growth and increased survival compared with an analogous cancer vaccine
formulated for intramuscular delivery. In the mouse models, the intranasal
vaccine formulation induced a stronger antigen-specific CD8+ T cell response in the mucosa than the
intramuscular formulation. Next steps include developing an intranasal
formulation of an existing vaccine for mucosal delivery and then evaluating
it in a clinical trial against an analogous vaccine delivered via
Published online March 14, 2013
Work unpatented; cancer
vaccine tested in study patented; licensing details available from the Curie Institute's Technology
Sandoval, F. et al. Sci.
Transl. Med.; published online Feb. 13, 2013;
Contact: Eric Tartour, Institut National de la Santé et de
la Recherche Médicale (INSERM), Paris, France
Contact: Federico Sandoval,
same affiliation as above
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