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Disease models

Inducible mouse model for Alzheimer's disease (AD)

Mice with inducible expression of Alzheimer-type b-amyloid (Ab) could be useful for studying AD pathology. The mice developed amyloid pathology and showed impairment of short- and long-term memory at about 12 months. In this model, acute doxycycline-induced suppression of amyloid production partially rescued deficits in short-term spatial memory, whereas longer-term suppression also led to improvements in long-term spatial memory and working memory. Next steps could include using the mice to evaluate AD therapeutics.

SciBX 6(9); doi:10.1038/scibx.2013.226
Published online March 7, 2013

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Melnikova, T. et al. J. Neurosci.; published online Feb. 27, 2013;
Contact: David R. Borchelt, University of Florida, Gainesville, Fla.
Contact: Alena Savonenko, The Johns Hopkins University School of Medicine, Baltimore, Md.