Thursday, February 28, 2013
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Induced pluripotent stem
(iPS) cell-derived astrocytes from patients with amyotrophic lateral
Astrocytes derived from
patient iPS cells could be useful for evaluating therapeutic candidates to
treat ALS. Astrocytes carrying an ALS-causing mutation in TAR DNA
binding protein 43 (TDP-43;
were generated from an iPS cell line derived from a patient with familial
ALS. In culture, the astrocytes showed mislocalization of the protein in the
cytoplasm and increased TDP-43 levels and decreased survival compared with
astrocytes generated from control iPS cell lines. Next steps could include
using the cell model to evaluate therapeutic candidates for ALS.
Published online Feb. 28, 2013
Patent and licensing status
Serio, A. et al. Proc.
Natl. Acad. Sci. USA; published online Feb. 11, 2013;
Contact: Siddharthan Chandran, The University of Edinburgh,
Contact: Tom Maniatis, Columbia University, New York, N.Y.
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