Thursday, February 14, 2013
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arrays for delivery of live adenovirus vaccines
A dissolvable microneedle
array could be used for transdermal delivery of adenovirus vaccines.
Recombinant human adenovirus type 5 vectors expressing chicken ovalbumin
or HIV gag polyprotein
antigens were formulated as a dry powder and incorporated into the matrix of
a dissolvable microneedle array. In mice, skin immunization using the
microneedle array led to antigen-specific CD8+ T cell responses that were comparable to those
induced by conventional injection routes for vaccine delivery. Next steps
include testing the microneedle arrays on cadaver skin and then in clinical
TheraJect Inc. was involved
in the study and has the dissolving microneedle arrays in preclinical
development to deliver therapeutics and vaccines.
Published online Feb. 14, 2013
Microneedle array covered
by multiple issued and pending patents; available for licensing from
Bachy, V. et al. Proc.
Natl. Acad. Sci. USA; published online Feb. 5, 2013;
Contact: Linda S. Klavinskis, King's College London School
of Medicine, London, U.K.
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