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Drug delivery

Adjuvant and antigen co-delivery with nickel-chelating lipid nanoparticles

Nickel-chelating lipid nanoparticles that co-deliver antigens and adjuvants could be useful for vaccine delivery. Nickel-chelating lipid nanoparticles were formulated to carry the adjuvants monophosphoryl lipid A or cholesterol-modified CpG oligodeoxynucleotides and histidine-tagged recombinant viral or bacterial antigens. In mice, injection of the particles resulted in fivefold to sevenfold higher antibody titers than co-delivery of adjuvant and antigen as separate entities. Next steps could include testing the efficacy of the lipid nanoparticles in mouse models for viral and bacterial infection.

SciBX 6(6); doi:10.1038/scibx.2013.152
Published online Feb. 14, 2013

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Fischer, N.O. et al. J. Am. Chem. Soc.; published online
Jan. 18, 2013;
Contact: Craig D. Blanchette, Lawrence Livermore National Laboratory, Livermore, Calif.
Contact: Paul D. Hoeprich, same affiliation as above