Thursday, February 14, 2013
Publication and contact
Adjuvant and antigen
co-delivery with nickel-chelating lipid nanoparticles
nanoparticles that co-deliver antigens and adjuvants could be useful for
vaccine delivery. Nickel-chelating lipid nanoparticles were formulated to
carry the adjuvants monophosphoryl lipid A or
cholesterol-modified CpG oligodeoxynucleotides and
histidine-tagged recombinant viral or bacterial antigens. In mice, injection
of the particles resulted in fivefold to sevenfold higher antibody titers
than co-delivery of adjuvant and antigen as separate entities. Next steps
could include testing the efficacy of the lipid nanoparticles in mouse models
for viral and bacterial infection.
Published online Feb. 14, 2013
Patent and licensing status
Fischer, N.O. et al. J.
Am. Chem. Soc.; published online
Jan. 18, 2013;
Contact: Craig D. Blanchette, Lawrence Livermore National
Laboratory, Livermore, Calif.
Contact: Paul D. Hoeprich, same affiliation as above
All contents Copyright © 1993-2016 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]