Thursday, February 14, 2013
Publication and contact
Adjuvant and antigen
co-delivery with nickel-chelating lipid nanoparticles
nanoparticles that co-deliver antigens and adjuvants could be useful for
vaccine delivery. Nickel-chelating lipid nanoparticles were formulated to
carry the adjuvants monophosphoryl lipid A or
cholesterol-modified CpG oligodeoxynucleotides and
histidine-tagged recombinant viral or bacterial antigens. In mice, injection
of the particles resulted in fivefold to sevenfold higher antibody titers
than co-delivery of adjuvant and antigen as separate entities. Next steps
could include testing the efficacy of the lipid nanoparticles in mouse models
for viral and bacterial infection.
Published online Feb. 14, 2013
Patent and licensing status
Fischer, N.O. et al. J.
Am. Chem. Soc.; published online
Jan. 18, 2013;
Contact: Craig D. Blanchette, Lawrence Livermore National
Laboratory, Livermore, Calif.
Contact: Paul D. Hoeprich, same affiliation as above
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