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Antiamyloid compounds that inhibit biofilm formation

In vitro studies suggest compounds that disrupt amyloid fibers could be useful for preventing biofilm formation. In a cell culture assay of biofilm formation by the commensal bacterium Bacillus subtilis, the benzoquinone AA-861 and the lactone parthenolide prevented biofilm formation. In vitro, the two compounds blocked amyloid formation by a variety of amyloid-forming proteins. Next steps could include optimizing and testing hit compounds for inhibition of biofilms formed by pathogenic bacteria.

SciBX 6(6); doi:10.1038/scibx.2013.149
Published online Feb. 14, 2013

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Romero, D. et al. Chem. Biol.; published online Jan. 24, 2013;
Contact: Roberto Kolter, Harvard Medical School, Boston, Mass.