Thursday, February 7, 2013
This week in
Pluripotent cell-specific inhibitors (PluriSIns) to reduce the tumorigenic
risk of stem cell-based therapies
that are selectively toxic to human pluripotent stem cells could reduce the
tumorigenic risk of stem cell-based therapies. Residual undifferentiated stem
cells in stem cell-derived cell therapies can lead to teratoma formation. A
screen of about 50,000 small molecules identified 15 PluriSIns that were
cytotoxic to human embryonic stem cells (ESCs) and induced pluripotent stem
(iPS) cells but not to differentiated cells derived from these stem cells. In
a mixture of differentiated and undifferentiated stem cells injected into
mice, none of the cell mixtures pretreated with the lead PluriSIn developed
teratomas, whereas all vehicle-treated cell mixtures did. Next steps include
examining the ability of PluriSIns to reduce the risk of teratoma formation in
Published online Feb. 7, 2013
Two patent applications
filed; available for licensing through Yissum,
the technology transfer company for The
Hebrew University of Jerusalem, and Roche
Ben-David, U. et al.
Cell Stem Cell; published online Jan. 9, 2013;
Contact: Nissim Benvenisty, The Hebrew University of Jerusalem,
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