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Drug platforms

Sortase-mediated modification of a targeted mAb to improve antigen delivery and presentation

Sortase-mediated modification of therapeutic mAbs could be useful for developing vaccines and therapeutics to treat viral infections. Sortase A was used to generate conjugate molecules consisting of 1 out of 19 different peptide epitopes of a mouse g-herpes virus (MHV-68) linked to a mAb against lymphocyte antigen 75 (LY75; DEC205). In mice, immunization with the conjugated mAb prior to infection with MHV-68 led to a 10-fold decrease of viral titers compared with immunization using free peptide epitopes. Next steps could include using the method to modify other antibody-based vaccines.

SciBX 6(4); doi:10.1038/scibx.2013.102
Published online Jan. 31, 2013

Patent pending covering use of sortase enzymes for protein modification; available for licensing

Swee, L.K. et al. Proc. Natl. Acad. Sci. USA; published online Jan. 7, 2013;
Contact: Hidde L. Ploegh, Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Cambridge, Mass.