Thursday, January 31, 2013
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palindromic repeats (CRISPR) RNA editing system to modify mammalian DNA
CRISPR-derived genome editing system could be used to modify mammalian DNA.
CRISPR is a bacterial immune response system that uses host-expressed
nucleases and RNA repeats to cleave foreign DNA. To adapt this system to cleave
and edit mammalian genomes, two separate teams designed a DNA vector that
expressed a bacteria-derived CRISPR-associated nuclease together with guide
RNAs that contained CRISPR features and homology similar to mammalian genes.
The system was used to induce site-specific insertions and deletions in
multiple genomic loci in cultured mouse and human cells. Next steps include
characterizing and optimizing the specificity of the approach (see CRISPR
genome editing, page 1).
SciBX 6(4); doi:10.1038/scibx.2013.101
Published online Jan. 31, 2013
Patent applications filed
for findings in both papers; licensing status undisclosed
Cong, L. et al. Science;
published online Jan. 3, 2013;
Contact: Feng Zhang, Broad Institute of MIT and Harvard, Cambridge,
Mali, P. et al. Science; published online Jan. 3, 2013;
Contact: George M. Church, Harvard Medical School, Boston, Mass.
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