Thursday, January 31, 2013
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Antigen-specific T cells
generated from induced pluripotent stem (iPS) cells derived for adoptive
Two separate groups showed
that iPS cells derived from mature CD8+ T cells can
be differentiated into antigen-specific T cells that may be useful for
overcoming T cell exhaustion during adoptive immunotherapy. Mature CD8+
T cells were reprogrammed into iPS cells and then differentiated into T cells
with the same functionality and antigen specificity as the original CD8+
T cells. One group used mature CD8+ T cells from an HIV-infected
patient to generate
T cells that showed antigen-specific activity against HIV p27 (nef). The other group used
CD8+ T cells from a patient with melanoma to generate T cells that
showed antigen-specific activity against melan-A (MLANA; MART1). Next steps for both
groups include testing the regenerated human T cells in animal models.
SciBX 6(4); doi:10.1038/scibx.2013.100
Published online Jan. 31, 2013
Patent application filed
for findings in first study; available for licensing from Megakaryon Corp.
Contact: Genjiro Miwa, Mgakaryon Corp., Tokyo, Japan
Findings in second study
unpatented; licensing status not applicable
Nishimura, T. et al.
Cell Stem Cell; published online Jan. 3, 2013;
Contact: Hiromitsu Nakauchi, The University of Tokyo, Tokyo,
Vizcardo, R. et al. Cell Stem Cell; published online Jan. 3, 2013;
Contact: Hiroshi Kawamoto, RIKEN Research Center for Allergy
and Immunology, Yokohama, Japan
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