Thursday, January 31, 2013
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Transgenic miniature pig
model for hypercholesterolemia and atherosclerosis
A transgenic miniature pig
model for hypercholesterolemia and atherosclerosis could aid the development
of imaging technologies, intravascular devices and therapeutics. Yucatan
miniature pigs were engineered to express a gain-of-function mutant of human proprotein convertase subtilisin/kexin type 9
(PCSK9) in the liver,
which causes hypercholesterolemia and accelerates atherosclerosis in humans.
Transgenic pigs fed a high-fat, high-cholesterol diet had severe
hypercholesterolemia and key pathophysiological features of human
atherosclerosis, and faster development of atherosclerotic lesions compared
with wild-type pigs fed the same diet. Ongoing studies include validating
some of the imaging techniques used for clinical atherosclerosis studies.
SciBX 6(4); doi:10.1038/scibx.2013.99
Published online Jan. 31, 2013
Patent application filed by
licensed to PixieGene A/S
Al-Mashhadi, R.H. et al.
Sci. Transl. Med.; published online Jan. 2, 2013;
Contact: Jacob F. Bentzon, Aarhus University Hospital, Aarhus,
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