Approach

Summary

Licensing status

Publication and contact information

Disease models

Mouse model for lymphocytic choriomeningitis virus (LCMV) infection that produces hemorrhagic-like disease

A new mouse model could be used to screen for therapeutics or test vaccines against arenavirus infections that cause hemorrhagic-like disease. The arenavirus LCMV normally causes only mild infections in humans and mice, although related arenaviruses are capable of causing severe disease including hemorrhagic fever. In a strain of mice susceptible to viruses, LCMV infection caused hemorrhagic pathology that was fatal in seven of eight mice. Next steps include investigating the host-virus interactions that contribute to hemorrhagic symptoms in the mouse model.

SciBX 6(4); doi:10.1038/scibx.2013.98
Published online Jan. 31, 2013

Mouse model patented; available for licensing

Schnell, F.J. et al. PLoS Pathog.; published online Dec. 27, 2012;
doi:10.1371/journal.ppat.1003073
Contact: Dan V. Mourich, Sarepta Therapeutics Inc., Cambridge, Mass.
e-mail:
dmourich@sareptatherapeutics.com