Thursday, January 31, 2013
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Assays & screens
DNA analysis of Pap smear
samples to detect ovarian and endometrial cancer
DNA sequencing of Pap smear
samples could help diagnose ovarian and endometrial cancer. In Pap smear
samples isolated from patients with endometrial or ovarian tumors, targeted
DNA amplification and sequencing identified tumor-associated mutations in all
24 endometrial cancer cases and 9 of 22 ovarian cancer cases. In Pap smear
samples from patients with cancer and healthy controls, a multiplexed test
that amplifies and sequences 50 commonly mutated genomic regions identified
mutations in all 14 cancer cases and none of the 14 controls. Next steps
include validating the PapGene test on a larger number of specimens to
determine its specificity and sensitivity.
Published online Jan. 31, 2013
Patent application filed;
available for licensing from The Johns Hopkins
Contact: Keith Baker, Technology Transfer, The Johns Hopkins
University, Baltimore, Md.
Kinde, I. et al. Sci.
Transl. Med.; published online Jan. 9, 2013;
Contact: Bert Vogelstein, Ludwig Center for Cancer Genetics
and Therapeutics, Baltimore, Md.
Contact: Luis A. Diaz Jr., same affiliation as above
Contact: Isaac Kinde, same affiliation as above
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