Thursday, January 24, 2013
This week in techniques
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spectroscopy to detect microcalcified breast cancer lesions
Studies of breast cancer
samples suggest diffuse reflectance spectroscopy could help detect
microcalcified breast cancer lesions during standard biopsies. Breast cancer
biopsy techniques target microcalcified lesions because lesions lacking
microcalcifications can result in false negative hits. In core biopsy samples
from 23 patients, diffuse reflectance spectra were obtained for cancerous
lesions with and without microcalcifications and for benign lesions. A
computational algorithm incorporating the spectra detected microcalcified
lesions with 97% positive predictive power and 88% negative predictive power.
Next steps include devising a miniature optical fiber probe to conduct the
studies with the needle device currently used in breast biopsies and conducting
a large-scale clinical trial.
Published online Jan. 24, 2013
Patent application filed by
Institutes of Technology and co-inventors; will be
available for licensing in the near future
Soares, J.S. et al.
Proc. Natl. Acad. Sci. USA; published online Dec. 24, 2012;
Contact: Maryann Fitzmaurice, Case Western Reserve
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