Thursday, January 17, 2013
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antibody-toxin fusion immunotoxins in algae
In vitro and mouse studies suggest algae chloroplasts could
be used to produce anticancer immunotoxin fusion proteins. Genetically
engineered green algae chloroplasts were used to produce an immunotoxin
fusion protein that combined a eukaryotic endotoxin and an antibody domain
targeting B cell-specific CD22. The algae-produced
immunotoxin-induced death of human B cell lymphoma cells but not normal human
B or T cells. In a mouse xenograft model of human lymphoma, the
algae-produced immunotoxins inhibited tumor progression and increased
survival compared with the antibody domain alone. Next steps include
designing a new fusion protein for testing in large animal models.
At least six companies have antibodies targeting CD22 in Phase II testing or
earlier to treat various cancers.
Published online Jan. 17, 2013
Patent application filed;
licensed to Sapphire Energy Inc., a biofuels
Tran, M. et al. Proc.
Natl. Acad. Sci. USA; published online
Dec. 10, 2012;
Contact: Stephen P. Mayfield, University of California, San
Diego, La Jolla, Calif.
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