Thursday, January 17, 2013
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pH (low) insertion peptides
(pHLIPs) for delivery of gold nanoparticles to tumors
pHLIPs could be used to
target gold nanoparticles to tumors, which tend to have lower pH than normal
tissue. pHLIPs are water-soluble polypeptides derived from the
bacteriorhodopsin C helix. In mice with human cervical cancer tumors,
intratumoral injection of pHLIP-conjugated gold nanoparticles led to a
sixfold increase in gold accumulation in tumor tissues compared with
injection of nonconjugated gold nanoparticles. Next steps include developing
nanoparticle coatings that could further increase bioavailability and tumor
targeting and reduce accumulation in off-target tissues.
SciBX 6(2); doi:10.1038/scibx.2013.45
Published online Jan. 17, 2013
Patented; use of
radionuclide-labeled pHLIPs as a diagnostic tool for imaging of acidic
tissues licensed to General Electric Co.; other diagnostic
applications and all therapeutic applications available for licensing
Yao, L. et al. Proc.
Natl. Acad. Sci. USA; published online
Dec. 24, 2012;
Contact: Oleg A. Andreev, University of Rhode Island, Kingston,
Contact: Donald M. Engelman, Yale University, New Haven, Conn.
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