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Drug delivery

Glycosylated triterpene-mediated transdermal delivery of macromolecules

Ex vivo studies suggest glycosylated triterpenes are capable of transdermal transport and could help mediate therapeutic macromolecule delivery. In porcine skin, glycosylated triterpenes (avicins) isolated from the desert plant Acacia victoriae were transported across the skin. In this model, coadministration of avicins with estradiol, dextran or insulin increased transdermal delivery compared with saline control administration. Next steps include designing molecules based on the avicin structure to act as chaperones for macromolecule delivery.

SciBX 6(1); doi:10.1038/scibx.2013.24
Published online Jan. 10, 2013

Patent application filed; available for licensing

Pino, C.J. et al. Proc. Natl. Acad. Sci. USA; published online Dec. 10, 2012;
doi:10.1073/pnas.1200942109
Contact: V. Prasad Shastri, Vanderbilt University, Nashville, Tenn.
e-mail:
prasad.shastri@gmail.com