Thursday, December 6, 2012
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microparticles for inducing immune tolerance
Mouse studies suggest
peptide-linked microparticles that induce immune tolerance could be useful
for treating immune-mediated diseases such as multiple sclerosis (MS). In a
mouse model of experimental autoimmune encephalomyelitis (EAE), i.v. infusion
microparticles linked to encephalitis-associated peptides induced tolerance
and decreased symptom severity compared with microparticles linked to a
control peptide. Next steps include evaluating other peptide-linked PLG
microparticles in models of other immune-mediated diseases (see Micromanaging
tolerance, page 7).
Published online Dec. 6, 2012
Patent pending; available
for licensing from the Myelin Repair Foundation
Getts, D.R. et al. Nat.
Biotechnol.; published online Nov. 18, 2012;
Contact: Stephen D. Miller, Northwestern University,
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