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Drug platforms

Peptide-linked microparticles for inducing immune tolerance  

Mouse studies suggest peptide-linked microparticles that induce immune tolerance could be useful for treating immune-mediated diseases such as multiple sclerosis (MS). In a mouse model of experimental autoimmune encephalomyelitis (EAE), i.v. infusion of polystyrene or poly(lactide-co-glycolide) (PLG) microparticles linked to encephalitis-associated peptides induced tolerance and decreased symptom severity compared with microparticles linked to a control peptide. Next steps include evaluating other peptide-linked PLG microparticles in models of other immune-mediated diseases (see Micromanaging tolerance, page 7).

SciBX 5(47); doi:10.1038/scibx.2012.1246
Published online Dec. 6, 2012

Patent pending; available for licensing from the Myelin Repair Foundation

Getts, D.R. et al. Nat. Biotechnol.; published online Nov. 18, 2012;
Contact: Stephen D. Miller, Northwestern University,
Evanston, Ill.