Thursday, December 6, 2012
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Assays & screens
microvesicles in the blood of patients with glioblastoma multiforme (GBM)
A microfluidic system for
profiling tumor-derived microvesicles in the blood of patients with GBM could
help guide treatment decisions. On a microfluidic chip, microvesicles were
first labeled with a protein-targeted antibody conjugated to a magnetic nanoparticle
and then detected by micro-NMR. The assay was able to distinguish between
blood samples from patients with GBM and those from healthy volunteers with
90% accuracy based on the expression of four protein markers on
microvesicles. In patients with GBM treated with Temodar temozolomide,
changes in microvesicle numbers and biomarker expression could be used to
distinguish responders from nonresponders. Next steps include expanding the
approach to other tumor types and developing a platform for comprehensive
analysis of microvesicle biomarkers, including proteins, mRNAs and microRNAs.
Merck & Co. Inc.
markets Temodar to treat GBM.
Published online Dec. 6, 2012
Patent application filed on
the micro-NMR system; unavailable for licensing
Shao, H. et al. Nat.
Med.; published online Nov. 11, 2012;
Contact: Ralph Weissleder, Massachusetts General Hospital, Boston,
Contact: Hakho Lee, same affiliation as above
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