Thursday, November 29, 2012
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Programmed cell death 1
T cells for HPV-positive head and neck cancer prognosis
In vitro and mouse studies suggest levels of PD-1-expressing
T cells could be useful as a prognostic marker and help guide treatment for
HPV-positive head and neck cancer. In 32 patients with HPV-positive head and
neck cancers, survival rates and levels of PD-1-expressing T cells were
higher than those for 32 patients with HPV-negative cancers. In a mouse HPV
tumor model, an antibody targeting the PD-1 ligand programmed
cell death 1 ligand 1 (CD274 molecule;
increased the antitumor effect of an HPV cancer vaccine targeting E7
transforming protein (human
papillomavirus-16; HpV16gp1) compared with control
antibodies. Next steps include validating the biomarker findings and testing
anti-PD-1 antibodies in clinical trials.
At least eight companies have antibodies targeting PD-1 or PD-L1 in Phase II
testing or earlier to treat various cancers.
SciBX 5(46); doi:10.1038/scibx.2012.1221
Published online Nov. 29, 2012
licensing not applicable
Badoual, C. et al.
Cancer Res.; published online Nov. 7, 2012;
Contact: Eric Tartour, Georges Pompidou European Hospital,
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