Thursday, November 29, 2012
Publication and contact
endothelial cells from amniotic stem cells
Cell culture and mouse
studies identified methods to reprogram amniotic cells into vascular
endothelial cells. In human amniotic cells, transfection with three
transcription factors-ETS variant gene 2 (ETV2),
leukemia virus integration 1 (FLI1)
erythroblastosis virus E26 oncogene homolog (ERG)-plus
competitive inhibition of transforming growth factor-b (TGFB;
TGF-b) led to
formation of cells with morphological, genetic and functional similarities to
natural vascular endothelial cells. In mice with damaged livers, implantation
of the induced vascular endothelial cells led to growth of functional hepatic
blood vessels, whereas implantation of control cells did not. Next steps
could include testing the effect of induced vascular endothelial cells in
mouse models of disease and scaling up production of the cells.
SciBX 5(46); doi:10.1038/scibx.2012.1218
Published online Nov. 29, 2012
Patent and licensing status
Ginsberg, M. et al. Cell;
published online Oct. 18, 2012;
Contact: Shahin Rafii, Weill Cornell Medical College, New
All contents Copyright © 1993-2017 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]