Thursday, November 29, 2012
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endothelial cells from amniotic stem cells
Cell culture and mouse
studies identified methods to reprogram amniotic cells into vascular
endothelial cells. In human amniotic cells, transfection with three
transcription factors-ETS variant gene 2 (ETV2),
leukemia virus integration 1 (FLI1)
erythroblastosis virus E26 oncogene homolog (ERG)-plus
competitive inhibition of transforming growth factor-b (TGFB;
TGF-b) led to
formation of cells with morphological, genetic and functional similarities to
natural vascular endothelial cells. In mice with damaged livers, implantation
of the induced vascular endothelial cells led to growth of functional hepatic
blood vessels, whereas implantation of control cells did not. Next steps
could include testing the effect of induced vascular endothelial cells in
mouse models of disease and scaling up production of the cells.
SciBX 5(46); doi:10.1038/scibx.2012.1218
Published online Nov. 29, 2012
Patent and licensing status
Ginsberg, M. et al. Cell;
published online Oct. 18, 2012;
Contact: Shahin Rafii, Weill Cornell Medical College, New
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