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Disease models

Mouse model for typhoid fever

A mouse model for gastroenteritis and typhoid fever caused by Salmonella enterica Typhi could be used to evaluate therapeutic candidates. Mice with a genetic deletion of toll-like receptor 11 (Tlr11), a mouse-specific innate immune system receptor that binds to a protein on the surface of S. enterica Typhi, developed enteropathic bacterial infection and had decreased survival compared with wild-type controls. Tlr11 knockout mice immunized with heat-killed S. enterica Typhi developed immunity to subsequent infection with live bacteria. Next steps could include using the mouse model to evaluate therapeutic candidates.

SciBX 5(46); doi:10.1038/scibx.2012.1217
Published online Nov. 29, 2012

Patent and licensing status undisclosed

Mathur, R. et al. Cell; published online Oct. 26, 2012;
Contact: Sankar Ghosh, Columbia University, New York, N.Y.