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Disease models

Long-term, prion-infected cultures of organotypic cerebellar slices to monitor neurodegeneration

Long-term, prion-infected organotypic cerebellar slices could be used to identify neuroprotective therapeutics more accurately than cell-based assays. In five-week-old, prion-infected murine organotypic cerebellar slices, progressive spongiform neurodegeneration developed, closely recapitulating prion disease. In the model, compounds known to suppress prion replication in vivo had neuroprotective effects, whereas those known to only suppress prion replication in cell culture did not. Next steps include using the system to screen for neuroprotective molecules.

SciBX 5(46); doi:10.1038/scibx.2012.1216
Published online Nov. 29, 2012

Unpatented; licensing status not applicable

Falsig, J. et al. PLoS Pathog.; published online Nov. 1, 2012;
Contact: Adriano Aguzzi, Institute of Neuropathology, Zurich, Switzerland