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Taste receptor type 2 member 38 (TAS2R38) genotyping for Gram-negative bacterial infection susceptibility

In vitro studies suggest TAS2R38 genotyping could help determine treatment regimens for Gram-negative bacterial infections. In human sinonasal cells, different genotypes of the TAS2R38 ion channel showed different levels of channel activation in response to molecules derived from Gram-negative bacteria. In human cells transfected with human TAS2R38 variants, Gram-negative bacterial killing was greater in cells with highly active channels than in those with less active channels. In patients with Gram-negative bacterial infections that did not respond to treatment and required surgery, none expressed the highly active TAS2R38 variant. Next steps include validating the association between TAS2R38 genotype and infection severity.

SciBX 5(44); doi:10.1038/scibx.2012.1175
Published online Nov. 8, 2012

Patent application filed; available for licensing

Lee, R.J. et al. J. Clin. Invest.;
published online Oct. 8, 2012;
Contact: Noam A. Cohen, University of Pennsylvania, Philadelphia, Pa.