Thursday, November 8, 2012
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Taste receptor type 2 member 38 (TAS2R38) genotyping for Gram-negative
bacterial infection susceptibility
In vitro studies suggest TAS2R38 genotyping could help
determine treatment regimens for Gram-negative bacterial infections. In human
sinonasal cells, different genotypes of the TAS2R38 ion channel showed
different levels of channel activation in response to molecules derived from
Gram-negative bacteria. In human cells transfected with human TAS2R38
variants, Gram-negative bacterial killing was greater in cells with highly
active channels than in those with less active channels. In patients with
Gram-negative bacterial infections that did not respond to treatment and
required surgery, none expressed the highly active TAS2R38 variant. Next
steps include validating the association between TAS2R38 genotype and
Published online Nov. 8, 2012
Patent application filed;
available for licensing
Lee, R.J. et al. J.
published online Oct. 8, 2012;
Contact: Noam A. Cohen, University of Pennsylvania, Philadelphia,
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