Thursday, November 8, 2012
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acid bacteria for treating inflammatory bowel disease (IBD)
acid bacteria could be useful for treating IBD. Two food-grade strains of
lactic acid bacteria were engineered to express the protease inhibitor
elafin, which is downregulated in the colons of patients with IBD. In a mouse
model of chemically induced colitis, oral delivery of the engineered
bacterial strain restored intestinal homeostasis and decreased gut
inflammation compared with wild-type bacteria. Next steps include evaluating
the safety of the engineered bacteria.
ViThera Pharmaceuticals Inc.
is developing the engineered bacteria for use in IBD (see IBD's bacteria
cafeteria, page 8).
Published online Nov. 8, 2012
Patented; licensed to
Motta, J.-P. et al. Sci.
published online Oct. 31, 2012;
Contact: Nathalie Vergnolle,
Institut National de
la Santé et de la Recherche
Médicale (INSERM), Toulouse, France
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