Thursday, November 8, 2012
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Xenograft mouse model for
pediatric acute megakaryoblastic leukemia (AMKL)
A mouse xenograft model for
pediatric AMKL could help identify new treatments for the cancer. Blast cells
from the blood or bone marrow of patients with pediatric AMKL were injected
into immunocompromised mice, with six of eight samples leading to successful
engraftment. The models recapitulated aspects of the human disease, including
low blast counts in the blood. In the model, the aurora
kinase A (AURKA;
decreased leukemic blast levels and the incidence of paralysis and increased
survival compared with placebo. Next steps include using this model to assess
the efficacy of additional therapeutic candidates.
Takeda Pharmaceutical Co. Ltd.'s
is in Phase III testing to treat peripheral T cell lymphoma (PTCL). The
compound also is in Phase II testing or earlier to treat other cancers.
Published online Nov. 8, 2012
Patent and licensing status
Thiollier, C. et al. J.
published online Oct. 8, 2012;
Contact: Thomas Mercher, Institut National de la Santé et de
la Recherche Médicale (INSERM), Vellejuif, France
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