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Disease models

NADPH oxidase 2 (Nox2)-deficient, lupus-prone mice

Nox2-deficient, lupus-prone mice could be useful models for severe systemic lupus erythematosus (SLE). The mice were generated by crossing Nox2-deficient animals with mice that had a lupus-prone genetic background. The resulting mice had severe lupus symptoms including increased spleen weights, more severe renal pathology and high autoantibody levels compared with lupus-prone mice that expressed Nox2. Next steps could include using the mice to evaluate treatments for SLE.

SciBX 5(44); doi:10.1038/scibx.2012.1171
Published online Nov. 8, 2012

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Campbell, A.M. et al. Sci. Transl. Med.; published online Oct. 24, 2012;
Contact: Mark J. Shlomchik, Yale School of Medicine, New Haven, Conn.