Thursday, October 25, 2012
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Expansion of embryonic stem
cell (ESC)-derived progenitors in organ-matched mesenchymal cultures
Expansion of ESC-derived
progenitors in organ-matched mesenchymal cell culture could be used to
generate adequate cell numbers for cell-based therapies. Coculture of human
ESC-derived pancreas endodermal cells and human primary pancreas mesenchymal
cells led to a 65 million-fold expansion of the endodermal cells. The expanded
endodermal cells could be differentiated into pancreatic progenitors that
developed into glucose-sensing, insulin-producing cells after being injected
under the kidney capsule in mice. In glucose tolerance tests, mice engrafted
with pancreatic progenitors had blood glucose levels similar to those in mice
engrafted with human islets. Next steps could include expansion of other
types of organ-specific cells.
Published online Oct. 25, 2012
Patent and licensing status
Sneddon, J.B. et al.
Nature; published online Oct. 7, 2012;
Contact: Douglas A. Melton, Harvard University, Cambridge,
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