Thursday, October 25, 2012
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Model for T cell therapy
resistance in melanoma
A mouse model for T cell
resistance suggests T cell-based melanoma therapies should target both
melanocytic and nonmelanocytic antigens to help prevent disease relapse. Mice
were engineered to develop melanomas driven by overexpression of hepatocyte growth factor/scatter factor
(Hgf/sf) and an oncogenic
mutation in cyclin dependent kinase 4
(Cdk4). In the mice,
acquired resistance to T cell therapies was linked to inflammation-induced
dedifferentiation and loss of melanocytic antigens in melanoma cells. Next
steps include developing more clinically relevant models to test potential
combinations of adoptive cell transfer therapies with marketed melanoma drugs
hidden act, page 1).
Published online Oct. 25, 2012
status not applicable
Landsberg, J. et al.
Nature; published online Oct. 10, 2012;
Contact: Thomas Tüting, University of Bonn, Bonn, Germany
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