Thursday, October 25, 2012
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Assays & screens
Multiplex screening for
interacting compounds (MuSIC) to help identify drug combinations to treat
MuSIC could be used to help
identify drug combinations to treat HIV infection. A primary screen using
pooled compounds to increase throughput was used to evaluate about 500,000
drug pairs of 1,000 FDA-approved or clinically tested compounds in
HIV-infected cells. The screen identified the glucocorticoid prednisolone
and the antiprotozoal nitazoxanide as the top synergistic
pair hit. The pair was confirmed by a separate screen and by two distinct
methods to quantify drug synergy. Additional cell-based studies showed that
prednisolone and nitazoxanide synergized with the HIV integrase inhibitor Isentress raltegravir.
Ongoing work includes testing other combinations identified in the study and
using MuSIC to identify combinations that could be used to treat other
infectious diseases, cancer or asthma.
Published online Oct. 25, 2012
status not applicable
Tan, X. et al. Nat.
Biotechnol.; published online Oct.14, 2012;
Contact: Stephen J. Elledge, Harvard Medical School and
Brigham and Women's Hospital, Boston, Mass.
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