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Drug platforms

Paper-based diagnostic for drug-associated hepatotoxicity

A paper-based method for detecting liver enzymes in the blood could be useful for detecting drug-related hepatotoxicity in the point-of-care setting. The method consists of a paper-based microfluidic device that detects the liver enzymes aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in a single drop of blood. In serum and whole-blood samples, the device generated colorimetric readouts that fell into one of three clinically relevant concentration ranges and showed over 90% accuracy. Next steps include testing the device in a third-world hospital setting in Vietnam.

SciBX 5(41); doi:10.1038/scibx.2012.1098
Published online Oct. 18, 2012

Findings patented; available for licensing from Diagnostics for All

Pollack, N.R. et al. Sci. Transl. Med.; published online Sept. 19, 2012;
Contact: Jason P. Rolland, Diagnostics for All, Cambridge, Mass.

Contact: Nira R. Pollock, Beth Israel Deaconess Medical Center, Boston, Mass.