Thursday, October 18, 2012
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Paper-based diagnostic for
A paper-based method for
detecting liver enzymes in the blood could be useful for detecting
drug-related hepatotoxicity in the point-of-care setting. The method consists
of a paper-based microfluidic device that detects the liver enzymes aspartate
aminotransferase (AST) and alanine
aminotransferase (ALT) in a single drop of blood. In
serum and whole-blood samples, the device generated colorimetric readouts
that fell into one of three clinically relevant concentration ranges and
showed over 90% accuracy. Next steps include testing the device in a
third-world hospital setting in Vietnam.
Published online Oct. 18, 2012
available for licensing from Diagnostics
Pollack, N.R. et al.
Sci. Transl. Med.; published online Sept. 19, 2012;
Contact: Jason P. Rolland, Diagnostics for All, Cambridge, Mass.
Contact: Nira R. Pollock, Beth Israel Deaconess Medical Center,
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