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Liposomal formulation of saxitoxin and dexamethasone to delay neuropathic pain

Studies in rats suggest a liposomal formulation of the sodium channel blocker saxitoxin and the glucocorticoid agonist dexamethasone could delay neuropathic pain. In a spared nerve injury rat model, three sequential injections of the saxitoxin and dexamethasone liposomal formulations increased mechanical and thermal withdrawal threshold compared with no treatment. Next steps could include technically refining the method and testing the formulation in large animal studies.

SciBX 5(41); doi:10.1038/scibx.2012.1095
Published online Oct. 18, 2012

Patent application filed; available for licensing

Shankarappa, S.A. et al. Proc. Natl. Acad. Sci. USA; published online Oct. 8, 2012;
Contact: Daniel S. Kohane, Boston Children's Hospital and Harvard Medical School, Boston, Mass.

Contact: Robert Langer, Massachusetts Institute of Technology, Cambridge, Mass.