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Disease models

Mouse model for nonalcoholic fatty liver disease

A mouse model of nonalcoholic fatty liver disease (NAFLD) could be used to help identify therapeutics. The I148M variant of patatin-like phospholipase domain containing 3 (PNPLA3; ADPN) is a risk factor for NAFLD. Mice that overexpressed the I148M variant of human PNPLA3 in the liver had a fatty liver phenotype and showed other metabolic features of NAFLD. In these mice, liver secretions showed less hydrolysis and higher levels of disease-causing triacylglycerol than liver secretions from wild-type controls. Next steps could include using the model to evaluate therapeutic candidates.

SciBX 5(41); doi:10.1038/scibx.2012.1093
Published online Oct. 18, 2012

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Li, J.Z. et al. J. Clin. Invest.; published online Oct. 1, 2012;
Contact: Helen H. Hobbs, The University of Texas Southwestern Medical Center, Dallas, Texas