Thursday, October 18, 2012
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Mouse model for
nonalcoholic fatty liver disease
A mouse model of
nonalcoholic fatty liver disease (NAFLD) could be used to help identify
therapeutics. The I148M variant of patatin-like phospholipase domain containing 3
is a risk factor for NAFLD. Mice that overexpressed the I148M variant of
human PNPLA3 in the liver had a fatty liver phenotype and showed other
metabolic features of NAFLD. In these mice, liver secretions showed less
hydrolysis and higher levels of disease-causing triacylglycerol than liver
secretions from wild-type controls. Next steps could include using the model
to evaluate therapeutic candidates.
Published online Oct. 18, 2012
Patent and licensing status
Li, J.Z. et al. J. Clin.
Invest.; published online Oct. 1, 2012;
Contact: Helen H. Hobbs, The University of Texas
Southwestern Medical Center, Dallas, Texas
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