Thursday, October 11, 2012
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RNA profiling to determine
prognosis in multiple sclerosis (MS)
Studies of patient samples
identified a transcriptional signature that could help determine MS
prognosis. Microarray data were generated for peripheral blood mononuclear
cells (PBMCs) isolated from 363 patients with MS who were previously
untreated or who had received interferon-b (IFNB;
IFN-b) or Copaxone
acetate. Unsupervised computational clustering of the subgroup
of 141 previously untreated patients identified 2 distinct gene expression
signatures that were correlated with significantly different rates of disease
activity (Cox proportional hazard ratio 0.6; p=0.0077). Next steps
include performing transcriptional analysis of subsets of purified blood
Copaxone glatiramer acetate
is marketed by Teva Pharmaceutical Industries Ltd. to
Biogen Idec Inc. markets Avonex
interferon beta-1a, Bayer AG markets Betaseron
interferon beta-1b and the Merck Serono S.A. division of Merck KGaA and Pfizer Inc. market Rebif
interferon beta-1a to treat MS.
Published online Oct. 11, 2012
status not applicable
Ottoboni, L. et al. Sci.
published online Sept. 26, 2012;
Contact: Philip L. De Jager, Brigham and Women's Hospital,
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