Thursday, October 11, 2012
Publication and contact
Fibroblast growth factor receptor 4 (FGFR4;
SNP as a response marker for pancreatic neuroendocrine tumors
A SNP in FGFR4 could
be used as a marker to predict pancreatic neuroendocrine tumor progression
and response to mammalian
target of rapamycin (mTOR;
inhibitors. In 71 patients with pancreatic neuroendocrine tumors, a
polymorphism in FGFR4 substituting an arginine for glycine at codon
388 was associated with larger, more aggressive and more invasive tumors. In
mice with human pancreatic neuroendocrine tumors, the mTOR inhibitor Afinitor
delayed growth and progression of tumors expressing FGFR4 G388 but not tumors
expressing FGFR4 R388. Next steps could include developing an assay to screen
patients for the FGFR4 SNP.
Novartis AG markets Afinitor to treat
multiple cancers and to prevent transplant rejection.
Published online Oct. 11, 2012
Patent and licensing status
S. et al. Cancer Res.;
published online Sept. 17, 2012;
Contact: Sylvia L. Asa, University Health Network, Toronto,
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