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Functionalized multiwalled carbon nanotubes as contrast agents for ultrasound imaging

Functionalized multiwalled carbon nanotubes could be used as contrast agents to enhance ultrasound imaging. Multiwalled carbon nanotubes were oxidized and then modified by adding azomethine ylides to make them biocompatible. In ex vivo studies using pig livers and hearts, injection of the carbon nanotubes increased ultrasound imaging contrast 20-fold compared with water. In pig studies, delivery of the carbon nanotubes to the bladder increased ultrasound imaging contrast compared with no treatment. Next steps could include evaluating the safety and pharmacokinetics of the carbon nanotubes.

SciBX 5(40); doi:10.1038/scibx.2012.1066
Published online Oct. 11, 2012

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Delogu, L.G. et al. Proc. Natl. Acad. Sci. USA; published online
Sept. 24, 2012;
Contact: Alberto Bianco, Institute of Molecular and Cellular Biology, Strasbourg, France

Contact: Lucia Gemma Delogu, University of Sassari, Sassari, Italy