Thursday, October 11, 2012
Publication and contact
Vascular catheters modified
to prevent thrombus formation and microbial attachment
modification of vascular catheters could help prevent catheter-associated
thrombosis and infection. Nonleaching polysulfobetaine was attached to the
inner surface of commercially available, peripherally inserted central
catheters. In a canine model of thrombosis, the polysulfobetaine-modified
catheter showed a 99% decrease in thrombus formation compared with an
unmodified catheter. The modified catheter also showed 97%-99.9% lower
adhesion of 5 tested microbes and 97% less biofilm formation with Staphylococcus
aureus than the unmodified catheter.
The Semprus BioSciences Corp. unit of Teleflex Inc. markets the
polysulfobetaine-modified catheter in the EU, and the product is under FDA
Published online Oct. 11, 2012
Covered by multiple issued
and pending patents; licensing status undisclosed
Smith, R.S. et al. Sci.
Transl. Med.; published online Sept. 26, 2012;
Contact: Christopher Loose, Semprus BioSciences Corp., Cambridge,
All contents Copyright © 1993-2016 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]