Thursday, October 11, 2012
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Vascular catheters modified
to prevent thrombus formation and microbial attachment
modification of vascular catheters could help prevent catheter-associated
thrombosis and infection. Nonleaching polysulfobetaine was attached to the
inner surface of commercially available, peripherally inserted central
catheters. In a canine model of thrombosis, the polysulfobetaine-modified
catheter showed a 99% decrease in thrombus formation compared with an
unmodified catheter. The modified catheter also showed 97%-99.9% lower
adhesion of 5 tested microbes and 97% less biofilm formation with Staphylococcus
aureus than the unmodified catheter.
The Semprus BioSciences Corp. unit of Teleflex Inc. markets the
polysulfobetaine-modified catheter in the EU, and the product is under FDA
Published online Oct. 11, 2012
Covered by multiple issued
and pending patents; licensing status undisclosed
Smith, R.S. et al. Sci.
Transl. Med.; published online Sept. 26, 2012;
Contact: Christopher Loose, Semprus BioSciences Corp., Cambridge,
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