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Assays & screens

NMR of hyperpolarized fluorine to characterize ligand-protein interactions

Hyperpolarized fluorine could improve the sensitivity of fluorine-based NMR for characterizing ligand-protein interactions. Samples were rapidly injected into an aliquot of hyperpolarized fluorine and analyzed by NMR. The use of hyperpolarized fluorine enabled generation of readable NMR spectra even when ligand and protein concentrations differed by up to six orders of magnitude, which enabled the calculation of Kd values. Next steps include using hyperpolarized fluorine in drug discovery efforts.

SciBX 5(40); doi:10.1038/scibx.2012.1061
Published online Oct. 11, 2012

Unpatented; licensing status not applicable

Lee, Y. et al. J. Am. Chem. Soc.; published online Sept. 28, 2012;
Contact: Christian Hilty, Texas A&M University, College Station, Texas